Abstract: The Guizhong depression with special geotectology conditions is bounded on the north by the Guibei antiklise and the Yangtze platform, on the west by the Youjiang regenerated geosyncline, and on the east and the south by the Dayaoshan rise. In the region, most of the Pb-Zn deposits in Guangxi Zhuang Autonomous Region are distributed around the Guizhong depression. The ultralarge scale and large-moderate scale Pb-Zn ore deposits of the Hechi-Nandan metallogenetic belt lie on the boundary of the west and the northwest of the depression, the deposits of the Wuxuan-Xiangzhou metallogenetic belt lie on the boundary of the east and the southeast of the depression, and many deposits such as Binyang, Guixian, Xijikeng, Beishan and Siding lie on the boundary of the south, the north, and the northeast. In the ore district, the occurrences of the orebodies are controlled principally by different geological surfaces like the plane of unconformity, the contact of some faults, the periphery of magmatic rock, the site of sedimentary facies change, and the contact areas of diverse lithofacies. Whether within the region or within the ore district, the mineralization and distribution of Pb-Zn deposits are evidently controlled by the geological surfaces. The characteristics demonstrate that Pb-Zn deposits around the Guizhong depression are very similar to the MVT Pb-Zn deposits in the Mississippi Valley, USA(MVT). The various geological surfaces are the district of the transmission, concentration, conversion and release of energy within the earth, and are the place of the change, the activation, the transportation and the precipitation of the materials of the earth, and are the locale of the mineralization. The geological surfaces in the joint of the Guizhong depression with the peripheral geological structure units are the favorable districts of the mineralization of the MVT type lead-zinc deposits.